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C-ProTrap Butyl resin is a chromatography media, can remove aggregates efficiently from antibodies, synthesized by standard polysaccharide ligand modification technology. After affinity chromatography like protein A, protein L or protein G, the antibody samples are passed through C-ProTrap Butyl chromatography, the aggregates are bound to the hydrophobic ligand of the chromatography media and antibody monomers are coming out in flowthrough fraction. C-ProTrap Butyl can be used as flow-through purification mode that selectively bounds such as aggregates or polymers.
Fig 1. OPM analysis of C-ProTrap Butylresin
Crosslinked spherical Cellulose beads are prepared by unique process from crystalline natural polysaccharides, differing the physical characteristics from noncrystalline polysaccharides such as agarose. Thus, C-ProTrap resins are highly porous in nature (Fig. 1). Due to that porous nature of the highly crosslinked spherical cellulose bead, resins have unique mechanical strength.
Partial structure of C-ProTrap Butyl
C-ProTrap Butyl enable high-flow operations, for efficient purification in biopharmaceutical industries high flow operation is essential. The figures below show pressure-flow velocity curves of C-ProTrap Butyl. C-ProTrap Butyl resin is operable at practical flow velocities and pressures.
C-ProTrap Butyl have high efficiency in mass transfer and excellent Dynamic Binding Capacities, particularly for large biomolecules like Immunoglobulins (IgG) also for HSA and Ribonuclease.
| Characteristics | |
|---|---|
| Ligand | Butyl group |
| Type | Hydrophobic |
| Base Matrix | Highly Cross-linked agarose Beads |
| Particle Size (µm) | 40–130 µm (Avg: 90 µm) |
| pH Working Range | 2–14 |
| Operating Pressure | Up to 2 bar (0.2 MPa) |
| Chemical Stability | 0.5 N NaOH |
| Dynamic Binding Capacity (mg/mL resin) |
HSA*: 35 Human IgG**: 12 |
| Supplied | Suspension in 20% Ethanol |
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