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GeloPure L

Affinity Chromatography Media

GeloPure L Resin

Introduction

GeloPure L resin is basically rProtein L immobilised agarose based an affinity chromatography media used for the purification of immunoglobulins (IgG), primarily monoclonal antibodies. The ligand, recombinant Protein L, is immobilized on a spherical crosslinked agarose resin for high binding capacity

Binding Mechanism of GeloPure L Resin

Protein L is a cell wall protein originally derived from Staphylococcus aureus. It specifically binds to the scFv (single-chain variable fragment) region of immunoglobulin G (IgG) molecules, making it ideal for antibody purification.

gelopure_l
GeloPure L Resin 100 mL
GeloPure L Resin 100 mL GeloPure L Resin 50 mL
GeloPure L Resin, 100 mL
High-performance resin for efficient biomolecule separation.
GP-L-100ML
On Request
GeloPure L Resin, 50 mL
High-performance resin for efficient biomolecule separation.
GP-L-50ML
On Request
Pack Size
100 mL
50 mL
Attribute GeloPure L
Ligand Recombinant Protein L
Matrix Crosslinked agarose beads 4%
Particle diameter (µm) 30–165
Ligand Coupling Covalent coupling via multipoint attachment
Dynamic Binding Capacity >10 mg/mL
Recommended CIP Solution 0.2 M NaOH, 0.2 M NaOH in 20% EtOH, 0.2 M NaOH in 95% EtOH
pH Stability Range 1–13
Storage 2–8 ºC in 20% ethanol
Protein Recovery Characteristics Possible to enter in the pore but low adsorption and high recovery under salt addition conditions
Shelf Life Typically, 1–2 years unopened
Technical Datasheet

Advantages

  • High selectivity for scFv region → high purity in one step.
  • High dynamic binding capacity (DBC ≥ 10 mg/mL).
  • Robust chemical stability → reusable for multiple cycles (up to 100+).
  • Compatible with CIP using NaOH, low pH elution, and other bioprocess conditions

Products

  • Weak Ion Exchange
  • Strong Ion Exchange
  • Affinity chromatographic Resins
  • Hydrophobic Resins
  • Chromatographic columns
  • Chromatographic systems
    (Under Development)

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