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Pro-Scale Columns

Pro-Scale Columns

Pre-packed chromatography columns are ready-to-use columns prefilled with stationary phase material (resins, beads, or gels) for liquid chromatography. They are widely used in research, biopharmaceutical manufacturing, and analytical labs for separation, purification, and analysis of biomolecules and small compounds.

Key Features of Pro-Scale Columns:-

Advanced Chromatography Columns for Optimal Performance

  • Adjustable Bed Height: Dynamic column bed height allows flexibility in packing volumes, optimizing performance for various applications.
  • Scalability : Seamlessly transition from lab-scale development to pilot and production scales with consistent efficiency
  • Durable Construction : Made from borosilicate glass and stainless steel components, ensuring high-pressure resistance and compatibility with diverse resins and solvents.
  • High-Performance Packing: Engineered for efficient and reproducible packing, delivering uniform flow distribution for high-resolution separations.
  • User-Friendly Operation: Features graduated glass columns for precise visual monitoring and a mechanical axial compression system for optimal resin compaction.
  • Versatile Compatibility : Supports various chromatography techniques, including ion exchange, size exclusion, and affinity chromatography.
  • Robust Pressure & Flow Handling : Designed for high flow rates and pressures, making it ideal for scale-up and large-scale production

Specifications:

  • Column Diameters: Available in various diameters (e.g., 10, 16, 26, 50 mm) to accommodate different scales of operation.
  • Bed Heights: Adjustable bed height ranging from a few centimeters to over 30 cm.
  • Pressure Ratings: High tolerance for pressures, often up to several bar (check product-specific details).
  • Glass tube: Provides visual monitoring.
  • End fittings: Stainless steel or polymer, ensuring durability

Applications:

  • Process Development: Fine-tuning chromatography parameters, including resin selection, flow rates, and bed height, to optimize purification efficiency. Assessing scalability and process feasibility for seamless implementation.
  • Pilot-Scale Purification: Facilitating the purification of monoclonal antibodies (mAbs), recombinant proteins, and enzymes, as well as supporting intermediate-scale biomolecule production.
  • Research & Development: – Investigating biomolecule behavior under various chromatographic conditions and evaluating new resins and ligands to enhance purification strategies.
  • Scale-Up Processes : Ensuring a smooth transition from laboratory-scale purification to full production, optimizing workflows for large-scale applications.

Maintenance and Care:-

  • Column Packing and Unpacking: Follow the manufacturer's guidelines for resin packing to ensure even distribution and minimize voids. Use the mechanical compression system to achieve optimal resin bed stability.
  • Cleaning-In-Place (CIP): Regularly clean the column using appropriate cleaning agents (e.g., NaOH or other compatible solutions). Remove residual contaminants or proteins to maintain efficiency.
  • Storage: IStore the column in a preservative solution (e.g., 20% ethanol) when not in use. Protect from physical damage and extreme environmental conditions.
  • Inspection: Periodically check seals, gaskets, and glass tubes for signs of wear or damage. Replace worn-out parts to maintain performance.

Advantages

  • High reproducibility and precision in scaling up processes.
  • Transparent construction for real-time monitoring
  • Broad compatibility with resins and applications.

Products

  • Weak Ion Exchange
  • Strong Ion Exchange
  • Affinity chromatographic Resins
  • Hydrophobic Resins
  • Chromatographic columns
  • Chromatographic systems
    (Under Development)

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