Cross-linked spherical Cellulose beads are prepared by unique process from crystalline natural polysaccharides, differing the physical characteristics from noncrystalline polysaccharides such as agarose. Thus, CelloPure resins are highly porous in nature (Fig.). Due to that porous nature of the highly cross-linked spherical cellulose bead, resins have unique mechanical strength. CelloPure CM, made from highly crosslinked cellulose beads, benefits from this structure by offering unique mechanical strength and efficient flow velocity for large biomolecules. This helps improve performance when purifying large proteins and other biological substances.