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CelloPureāŗ Phenyl

Hydrophobic Chromatography Media

CelloPureāŗ Phenyl

Introduction

CelloPureāŗ Phenyl resin is a chromatography media, can remove aggregates efficiently from antibodies, synthesized by standard polysaccharide ligand modification technology. After affinity chromatography like protein A, protein L or protein G, the antibody samples are passed through CelloPureāŗ Phenyl chromatography, the aggregates are bound to the hydrophobic ligand of the chromatography media and antibody monomers are coming out in flowthrough fraction. CelloPureāŗ Phenyl can be used as flow-through purification mode that selectively bounds such as aggregates or polymers.

DC-ProTrap Phenyl

 Fig 1. OPM analysis of CelloPureāŗ Phenyl resin

CelloPureāŗ Phenyl base resin

Crosslinked spherical Cellulose beads are prepared by unique process from crystalline natural polysaccharides, differing the physical characteristics from noncrystalline polysaccharides such as agarose. Thus, Biotrap resins are highly porous in nature (Fig. 1). Due to that porous nature of the highly crosslinked spherical cellulose bead, resins have unique mechanical strength.

pro_phenyl.formula

Partial structure of CelloPureāŗ Phenyl

Ligand structure for CelloPureāŗ Phenyl media is described.

Pressure-flow Properties of CelloPureāŗ Phenyl

CelloPureāŗ Phenyl enable high-flow operations, for efficient purification in biopharmaceutical industries high flow operation is essential. The figures below show pressure-flow velocity curves of CelloPureāŗ Phenyl (Fig. 3). CelloPureāŗ Phenyl is operable at practical flow velocities and pressures.

phenyl_sheet

Dynamic Binding Capacities of CelloPureāŗ Phenyl

CelloPureāŗ Phenyl have high efficiency in mass transfer and excellent Dynamic Binding Capacities, particularly for large biomolecules like Immunoglobulins (IgG) also for HSA (Human Normal Albumin) and Ribonuclease. Because of these special qualities, CelloPure CM media can be used in downstream processes in the purification of biopharmaceuticals.

graph_cellopure_phenyl
CelloPureāŗ Phenyl 100 mL
CelloPureāŗ Phenyl100 mL CelloPureāŗ Phenyl50 mL
CelloPureāŗ Phenyl, 100 mL
High-performance resin for efficient biomolecule separation.
CP-PHENYL-100ML
On Request
CelloPureāŗ Phenyl, 50 mL
High-performance resin for efficient biomolecule separation.
CP-PHENYL-50ML
On Request
Pack Size
100 mL
50 mL

The basic characteristics of CelloPureāŗ Phenyl Resin are shown in table 1

Characteristics
Ligand Phenyl group
Type Hydrophobic
Base Matrix Highly Cross-linked Dextran scaffold Cellulose Beads
Particle Size (Āµm) 40 Āµm to 130 Āµm (Avg: 90 Āµm)
pH Working Range 2 to 14
Operating Pressure Up to 2 bar (0.2 Mpa)
Chemical Stability 0.5N NaOH
Binding Capacity
(mg/mL resin)		 HSA*: 60
Human-IgG**: 20
Supplied Suspension in 20% Ethanol
Technical Datasheet

Advantages:

  • Superior Selectivity ā€“ The phenyl ligand ensures precise separation of hydrophobic biomolecules, ideal for complex protein mixtures.
  • High Stability ā€“ Crosslinked cellulose matrix withstands high flow rates and harsh cleaning protocols, ensuring durability.
  • Scalable Efficiency ā€“ Seamlessly supports purification from lab-scale experiments to large-scale biopharma production.
Achieve exceptional purification precision with BioTrap Phenyl!

Products

  • Weak Ion Exchange
  • Strong Ion Exchange
  • Affinity chromatographic Resins
  • Hydrophobic Resins
  • Chromatographic columns
  • Chromatographic systems
    (Under Development)

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